Furthermore, conventional multilamellar vesicles (MLVs), characterized by their concentric, onion-like lipid bilayers, fail to provide a definitive solution. Although they offer greater lipid mass, the aqueous volume fraction remains severely constrained by the tight inter-lamellar spacing. For R&D teams, this translates into a persistent formulation dilemma: attempting to force high doses of water-soluble therapeutics into these structures frequently results in uncontrolled burst release upon administration.
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