Phage Display for Antibody Humanization Antibody humanization is rarely a single-step sequence conversion. Even when germline frameworks are chosen based on high homology, subtle framework–CDR incompatibilities can distort paratope geometry, reduce expression, or change biophysical behavior. This is particularly common when humanizing antibodies from mouse and rabbit origins, and it can also occur when humanizing VHH-derived binders where framework composition is a major determinant of solubility and stability.
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